Papers of the Month

• TUBEs at work. GST-TUBEs: Enriching ubiquitylated biomarkers and targets for drug discovery at low cost is getting easier. Read the paper.

• Cleavable SUMOstar Fusions enable the expression and immunoaffinity purification of recombinant dengue virus 2 NS1. To read more click here.

• LifeSensors’ Technology at Work: A new research article demonstrates the selectrivity of Progenra’s novel anti-tumor compound using small molecule inhibitors (PR-619) and DUBs. For more information on DUBs activity, check out this paper.

• Identifying substrates for ubiquitin ligases is the biggest challenge In Cell Biology today. The application of modern tools, including LifeSensors’s Ligase Platform, are employed in this recent paper. 

Product Highlights

• NEW additions to our Ub/Ubl Pathway Inhibitors: Proteasome, Conjugating Enzyme, P97, and DUB Inhibitors are now available under Ubiquitin Research Tools. These tools are for research purposes only.

• LifeSensors is pleased to announce UbiQuant™, the first sandwich ELISA kit that captures total ubiquitin (mono- and poly-ubiquitylated conjugates) in biological samples.

• LifeSensors has developed the best anti-ubiquitin antibody (VU-1) for multiple applications. This antibody reacts with mono- and polyubiquitylated proteins in Western blot analysis and is an excellent reagent for the identification of ubiquitylated proteins in cells and tissue sections (IHC/IF).

SUMO Expression Systems

LifeSensors’ SUMO technologies are proven to dramatically enhance expression and solubility of heterologous proteins. Our SUMO proteases efficiently remove the SUMO fusion tags, leaving no residues behind, giving you the unaltered protein you designed. The His6-tags make purification fast and simple.

Ubiquitin Research Tools

LifeSensors offers the largest selection of Ubiquitin Research Tools.  Our dedication to the development of innovative regeants and tools allow researchers to investigate the ubiquitin proteasome pathway with ease of mind.

• Deubiquitylases (DUBs)   • Substrates   • Ubiquitin Conjugation Kits 

       • DUB Assay Kits    • Enzymes   • Ubiquitin Affinity Reagents   • Antibodies

Custom Biochemical Services

LifeSensors' offers a variety of biochemical services that can be customized to suite your needs.

Our custom services include: Protein Expression and Purification, Custom Substrate and Assay Development,  and  a variety of Microarray-based Services for Ligase Substrate Identification and for Deubiquitylase Substrate Identification.

Upcoming Meetings

Learn more about LifeSensors.

 Representatives will be attending the following meetings: 

• ASCB 2012   • PEGS 2012   •  Ubiquitin Drug Disovery &Diagnostics 2012
•  EB 2012   •  SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases 

Newsletter

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Technical Document Library

A complete listing of all documentation on our website for quick access and download.  Included are White Papers, Manuals, Plasmid Maps, Application Notes, and Poster Presentations.