Welcome to LifeSensors
A leading producer of tools that facilitate the study of the Ubiquitin Proteasome Pathway (UPP) and developer of novel technologies that use SUMO to overcome bottlenecks in protein production.
Ubiquitin Research Tools: Novel technologies such as the CHOP Reporter System allow researchers to demonstrate novel isopeptidase activity, determine substrate specificity of a Ub/Ubl isopeptidase, and measure activity of difficult enzymes such as the Cop9 signalosome. LifeSensors' Ubiquitin E3 Ligase Assay Kit combines the power of quantitative assesment of polyubiquitination with the ease and flexibility of 96-well modular "ELISA-like" platform format. The Ubiquitin E3 Ligase Assay Kit allows the screening of agonistic of antagonistic molecules of ligase activity, as well as E2/E3 pair profiling.
Expression Technologies: LifeSensors has patented the use of SUMO (Small Ubiquitin-like Modifier) as a fusion tag for recombinant protein expression in eukaryotic and prokaryotic systems. Benefits of this system include improved solubility and dramatically increased yield of the protein of interest. In addition, the tag is efficiently and cost effectively removed with no residual residues or “ragged” ends often associated with competing technologies.
Services: LifeSensors will work with you to identify and develop the appropriate SUMO expression system that is most effective for your therapeutic protein. LifeSensors can bring its in-house team to bear on the project by optimizing expression of the protein, identifying the best host for expression and developing a cost effective purification process.
